Recurrent Implantation Failure Clinic

Recurrent Implantation Failure Clinic

Sengclinic new recurrent implantation failure clinic aims to improve success rates for patients who have had failed fertility treatment despite using good quality embryos by assessing the endometrium (womb lining). This new clinic service has been set up by Dr Seng Shay Way who is one of the pioneers of endometrial biopsy in singapore.

Repeated implantation failure is a hugely frustrating experience and can be defined as the lack of pregnancy following the transfer of 3 or 4 good quality blastocysts (day 5 embryos) during fertility treatment.

Until now treatments have been tried ‘blindly’ without a diagnosis of what may be wrong with the endometrium. The clinic aims to improve success rates by using a range of tests to assess uterine receptivity and subsequently creating a personalised treatment plan for each patient based on the results.

Who will it benefit?

The new clinic will benefit patients who have had failed treatment cycles with good quality embryos following: IVF ,ICSI or ICSI with Preimplantation Genetic Screening (PGT-A), Egg donation.

How does it work?

The first step is to arrange a consultation with Dr Seng . This can either be via a referral from your current consultant or a self-referral to the clinic via our enquiries team in which your eligibility for the clinic can be discussed. At this appointment, the approach and process will be explained to you. You will be given some medication in preparation for the tests which will be planned for your next cycle. These tests will take place during a specific time during your cycle and will include:
  1. Hormonal blood tests
  2. Pelvic ultrasound scans
  3. An endometrial biopsy

Endometrial biopsy

Endometrial biopsy

An endometrial biopsy is similar to a smear test. A speculum is inserted in to the vagina and a small thin plastic tube is passed through the cervix to retrieve a sample of the tissue lining your womb (endometrium).

Fragments of the biopsy will be sent to different laboratories to identify a possible cause for implantation failure and to determine which treatment would be most appropriate. This may include changing the timing of your embryo transfer, additional medication. In some cases, the results will show that the receptivity is already optimal and no change in your treatment is indicated.

Follow up consultation

Your results will be ready in four to five weeks and reviewed with you during a follow up consultation where a specific treatment plan will be set depending on the findings.

For a limited number of patients these tests may not find any abnormalities and in exceptional cases the tests may need to be repeated.


The recurrent Implantation failure Clinic is a new concept introduced by Dr Seng shay Way. The tests used have been shown in published studies to provide information that can guide further treatment and improve clinical outcomes.